Rocky Mountain Spotted Fever (RMSF)
Information for Veterinarians
Rocky Mountain spotted fever (RMSF) is an important zoonotic disease that causes clinical illness in both dogs and humans. It is caused by the organism Rickettsia rickettsii, a small gram-negative obligate intracellular parasite from the family Rickettsiaceae. RMSF was first recognized in humans in the western United States during the 1930's but, despite its name, RMSF is less common in the Rocky Mountain region than in other areas of the United States. Although it has been long identified as a human pathogen, RMSF was not recognized in dogs until the 1970's¹²
Hard-bodied ticks are the vectors of RMSF, and there are several species that have been known to be involved in its transmission. The most common vector in the eastern United States is Dermacentor variabilis (the American dog tick). In Arizona, Rhipicephalus sanguineous is the most common vector while in other parts of the western United States Dermacentor andersoni (the wood tick) is responsible for most infections.
R. rickettsii is transmitted to the dog through the bite of an infected tick. Once inside the body, the organism undergoes a 2-14 day incubation period. The organism then invades endothelial cells of the venules and capillaries and begins replicating, causing a vasculitis. The replication of R. rickettsii and subsequent vasculitis may lead to edema, hemorrhage, shock, and vascular collapse. Endarterial organs (brain, skin, heart and kidneys) are affected most often. Vascular leakage also triggers activation of the animal's platelets and coagulation system.
Signs and Symptoms
Symptoms usually appear 4 or 5 days following a tick bite and almost always include:
- Fever (39.2°C [102.6°F] to 40.5°C [104.9°F]) and
- Severe lethargy
Other symptoms that may occur are:
- Petechiae and ecchymoses on oral, nasal, ocular, and genital mucous membranes
- Focal retinal hemorrhages
- Edema of the extremities and/or lips, pinna of ears, penile sheath, and scrotum.
In late-stage disease or during recovery, symptoms may include:
- Necrosis (acryl gangrene) of the extremities
- Abdominal pain, vomiting, and/or anorexia
- Altered mental status (signs of depression, stupor)
- Myalgia and/or polyarthritis
- Vestibular deficits (circling, head tilt, or nystagmus)
- Dyspnea or cough
Such signs indicate more disseminated lesions, substantial organ edema, and a worse prognosis.
The most likely abnormal clinical laboratory findings are:
- Moderate leukocytosis (minimal left shift)
Platelet counts usually range from 25,000 to 250,000/µL. If hypoalbuminemia develops, it probably results from widespread damage to the vascular endothelium and subsequent intercellular leakage. In dogs that are examined primarily because of cough or dyspnea, thoracic radiography typically reveals diffuse interstitial densities (pneumonitis). Clinical RMSF may also resemble infection with Ehrlichia canis, which is also transmitted by the brown dog tick, although RMSF tends to be more severe.
The antibiotic of choice for treating RMSF in dogs is doxycycline (10 to 20 mg/kg [4.5 to 9.1 mg/lb]). Mortality from RMSF is directly related to incorrect treatment, delayed diagnosis, or both. Appropriate antibiotic treatment promptly reduce the severity of illness only if they are given before tissue necrosis (thrombotic lesions) or coagulation disorders develop. Naturally acquired immunity most likely plays a role in limiting or protecting against clinical illness. Healthy dogs from endemic areas often possess anti-Spotted Fever Group (SFG) antibodies, possibly a result of prior R. rickettsii infection or exposure to nonpathogenic SFG rickettsiae.
The gold standard serologic test for diagnosis of RMSF is the indirect immunofluorescence assay (IFA) with R. rickettsii antigen, performed on two paired serum samples to demonstrate a significant (four-fold) rise in antibody titers. The first sample should be taken as early in the disease as possible, preferably in the first week of symptoms, and the second sample should be taken 2 to 4 weeks later. Often the first IgG IFA titer is typically low or negative, and the second typically shows a significant (fourfold) increase in IgG antibody levels. IgM antibodies usually rise at the same time as IgG near the end of the first week of illness and remain elevated for months or even years. Also, IgM antibodies are less specific than IgG antibodies and more likely to result in a false positive. For these reasons, veterinarians requesting IgM serologic titers should also request a concurrent IgG titer.
Both IgM and IgG levels may remain elevated for months or longer after the disease has resolved, or may be detected in dogs that were previously exposed to antigenically related organisms. Because there is no widely available rapid laboratory assay to provide early confirmation of RMSF, specific antibiotic treatment decisions should be made on the basis of epidemiologic and clinical clues rather than awaiting laboratory confirmation.
The best method to prevent RMSF in dogs is to prevent tick attachment. A topical or systemic tick-control treatment such as permethrin, fipronil, seasonal dips, or the use of impregnated collars containing amitraz or propoxur to prevent ticks is recommended. In areas with a high tick population and/or human cases of RMSF, regular applications of an acaricidal treatment to kennels and yards can reduce the number of ticks in a dog's environment. Brown dog ticks have also been found inside homes when dogs are permitted to come inside, and inside treatments from experienced pesticide technicians may be required to control infestations. Any ticks attached to dogs should be promptly and carefully removed using forceps or gloved hands. There are no anti-rickettsial vaccines available for use in either dogs or humans.
- Warner RD, Marsh WW: Rocky Mountain Spotted Fever. J Vet Intern Med, 10:1413-1417, 2002.
- Greene CE: Infectious Diseases of the Dog and Cat, 2nd ed. WB Saunders and Co., Philadelphia, 1998, pp. 155-162.